Phase II clinical and exploratory biomarker study of dacomitinib in patients with recurrent and/or metastatic squamous cell carcinoma of head and neck.
Identifieur interne : 000382 ( Main/Exploration ); précédent : 000381; suivant : 000383Phase II clinical and exploratory biomarker study of dacomitinib in patients with recurrent and/or metastatic squamous cell carcinoma of head and neck.
Auteurs : Han Sang Kim [Corée du Sud] ; Hyeong Ju Kwon [Corée du Sud] ; Inkyung Jung [Corée du Sud] ; Mi Ran Yun [Corée du Sud] ; Myung-Ju Ahn [Corée du Sud] ; Byung Woog Kang [Corée du Sud] ; Jong-Mu Sun [Corée du Sud] ; Sung Bae Kim [Corée du Sud] ; Dok-Hyun Yoon [Corée du Sud] ; Keon Uk Park [Corée du Sud] ; Se-Hoon Lee [Corée du Sud] ; Yoon Woo Koh [Corée du Sud] ; Se Hun Kim [Corée du Sud] ; Eun Chang Choi [Corée du Sud] ; Dong Hoe Koo [Corée du Sud] ; Jin Hee Sohn [Corée du Sud] ; Bomi Kim [Corée du Sud] ; Nak-Jung Kwon [Corée du Sud] ; Hwan Jung Yun [Corée du Sud] ; Min Goo Lee [Corée du Sud] ; Ji Hyun Lee [Corée du Sud] ; Tae-Min Kim [Corée du Sud] ; Hye Ryun Kim [Corée du Sud] ; Joo Hang Kim [Corée du Sud] ; Soonmyung Paik [Corée du Sud] ; Byoung Chul Cho [Corée du Sud]Source :
- Clinical cancer research : an official journal of the American Association for Cancer Research [ 1078-0432 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Analyse de profil d'expression de gènes, Analyse de regroupements, Antinéoplasiques (administration et posologie), Antinéoplasiques (effets indésirables), Antinéoplasiques (usage thérapeutique), Carcinome épidermoïde (anatomopathologie), Carcinome épidermoïde (génétique), Carcinome épidermoïde (mortalité), Carcinome épidermoïde (traitement médicamenteux), Dosage génique, Facteurs de risque, Femelle, Humains, Inhibiteurs de protéines kinases (administration et posologie), Inhibiteurs de protéines kinases (effets indésirables), Inhibiteurs de protéines kinases (usage thérapeutique), Marqueurs biologiques, Mutation, Mâle, Métastase tumorale, Pronostic, Quinazolinones (administration et posologie), Quinazolinones (effets indésirables), Quinazolinones (usage thérapeutique), Reprise du traitement, Récidive tumorale locale, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs de la tête et du cou (anatomopathologie), Tumeurs de la tête et du cou (génétique), Tumeurs de la tête et du cou (mortalité), Tumeurs de la tête et du cou (traitement médicamenteux).
- MESH :
- administration et posologie : Antinéoplasiques, Inhibiteurs de protéines kinases, Quinazolinones.
- anatomopathologie : Carcinome épidermoïde, Tumeurs de la tête et du cou.
- effets indésirables : Antinéoplasiques, Inhibiteurs de protéines kinases, Quinazolinones.
- génétique : Carcinome épidermoïde, Tumeurs de la tête et du cou.
- mortalité : Carcinome épidermoïde, Tumeurs de la tête et du cou.
- traitement médicamenteux : Carcinome épidermoïde, Tumeurs de la tête et du cou.
- usage thérapeutique : Antinéoplasiques, Inhibiteurs de protéines kinases, Quinazolinones.
- Adulte, Adulte d'âge moyen, Analyse de profil d'expression de gènes, Analyse de regroupements, Dosage génique, Facteurs de risque, Femelle, Humains, Marqueurs biologiques, Mutation, Mâle, Métastase tumorale, Pronostic, Reprise du traitement, Récidive tumorale locale, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antineoplastic Agents (administration & dosage), Antineoplastic Agents (adverse effects), Antineoplastic Agents (therapeutic use), Biomarkers, Carcinoma, Squamous Cell (drug therapy), Carcinoma, Squamous Cell (genetics), Carcinoma, Squamous Cell (mortality), Carcinoma, Squamous Cell (pathology), Cluster Analysis, Female, Gene Dosage, Gene Expression Profiling, Head and Neck Neoplasms (drug therapy), Head and Neck Neoplasms (genetics), Head and Neck Neoplasms (mortality), Head and Neck Neoplasms (pathology), Humans, Male, Middle Aged, Mutation, Neoplasm Metastasis, Neoplasm Recurrence, Local, Prognosis, Protein Kinase Inhibitors (administration & dosage), Protein Kinase Inhibitors (adverse effects), Protein Kinase Inhibitors (therapeutic use), Quinazolinones (administration & dosage), Quinazolinones (adverse effects), Quinazolinones (therapeutic use), Retreatment, Risk Factors, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antineoplastic Agents, Protein Kinase Inhibitors, Quinazolinones.
- chemical , adverse effects : Antineoplastic Agents, Protein Kinase Inhibitors, Quinazolinones.
- chemical , therapeutic use : Antineoplastic Agents, Protein Kinase Inhibitors, Quinazolinones.
- drug therapy : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- genetics : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- mortality : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- pathology : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- Adult, Aged, Aged, 80 and over, Biomarkers, Cluster Analysis, Female, Gene Dosage, Gene Expression Profiling, Humans, Male, Middle Aged, Mutation, Neoplasm Metastasis, Neoplasm Recurrence, Local, Prognosis, Retreatment, Risk Factors, Treatment Outcome.
Abstract
The goals of this study were to investigate the clinical activity, safety, and biomarkers of dacomitinib, an irreversible tyrosine kinase inhibitor of EGFR, HER2, and HER4, in recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M-SCCHN).
DOI: 10.1158/1078-0432.CCR-14-1756
PubMed: 25424851
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000739
- to stream PubMed, to step Curation: 000739
- to stream PubMed, to step Checkpoint: 000739
- to stream Ncbi, to step Merge: 003F60
- to stream Ncbi, to step Curation: 003F60
- to stream Ncbi, to step Checkpoint: 003F60
- to stream Main, to step Merge: 000382
- to stream Main, to step Curation: 000382
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Phase II clinical and exploratory biomarker study of dacomitinib in patients with recurrent and/or metastatic squamous cell carcinoma of head and neck.</title><author><name sortKey="Kim, Han Sang" sort="Kim, Han Sang" uniqKey="Kim H" first="Han Sang" last="Kim">Han Sang Kim</name><affiliation wicri:level="3"><nlm:affiliation>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul, Korea. Department of Pharmacology, Pharmacogenomic Research Center for Membrane Transporters, Brain Korea 21 PLUS Project for Medical Science, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul, Korea. Department of Pharmacology, Pharmacogenomic Research Center for Membrane Transporters, Brain Korea 21 PLUS Project for Medical Science, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kwon, Hyeong Ju" sort="Kwon, Hyeong Ju" uniqKey="Kwon H" first="Hyeong Ju" last="Kwon">Hyeong Ju Kwon</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pathology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jung, Inkyung" sort="Jung, Inkyung" uniqKey="Jung I" first="Inkyung" last="Jung">Inkyung Jung</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biostatistics, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biostatistics, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yun, Mi Ran" sort="Yun, Mi Ran" uniqKey="Yun M" first="Mi Ran" last="Yun">Mi Ran Yun</name><affiliation wicri:level="1"><nlm:affiliation>JE UK Institute for Cancer Research, Gumi City, Kyungbuk, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>JE UK Institute for Cancer Research, Gumi City, Kyungbuk</wicri:regionArea><wicri:noRegion>Kyungbuk</wicri:noRegion></affiliation></author><author><name sortKey="Ahn, Myung Ju" sort="Ahn, Myung Ju" uniqKey="Ahn M" first="Myung-Ju" last="Ahn">Myung-Ju Ahn</name><affiliation wicri:level="3"><nlm:affiliation>Samsung Medical Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Samsung Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kang, Byung Woog" sort="Kang, Byung Woog" uniqKey="Kang B" first="Byung Woog" last="Kang">Byung Woog Kang</name><affiliation wicri:level="1"><nlm:affiliation>Kyungpook National University Hospital, Daegu, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Kyungpook National University Hospital, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Jong Mu" sort="Sun, Jong Mu" uniqKey="Sun J" first="Jong-Mu" last="Sun">Jong-Mu Sun</name><affiliation wicri:level="3"><nlm:affiliation>Samsung Medical Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Samsung Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Sung Bae" sort="Kim, Sung Bae" uniqKey="Kim S" first="Sung Bae" last="Kim">Sung Bae Kim</name><affiliation wicri:level="3"><nlm:affiliation>Asan Medical Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Asan Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yoon, Dok Hyun" sort="Yoon, Dok Hyun" uniqKey="Yoon D" first="Dok-Hyun" last="Yoon">Dok-Hyun Yoon</name><affiliation wicri:level="3"><nlm:affiliation>Asan Medical Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Asan Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Keon Uk" sort="Park, Keon Uk" uniqKey="Park K" first="Keon Uk" last="Park">Keon Uk Park</name><affiliation wicri:level="1"><nlm:affiliation>Keimyung University, Daegu, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Keimyung University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Se Hoon" sort="Lee, Se Hoon" uniqKey="Lee S" first="Se-Hoon" last="Lee">Se-Hoon Lee</name><affiliation wicri:level="3"><nlm:affiliation>Seoul National University Hospital, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul National University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Koh, Yoon Woo" sort="Koh, Yoon Woo" uniqKey="Koh Y" first="Yoon Woo" last="Koh">Yoon Woo Koh</name><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Se Hun" sort="Kim, Se Hun" uniqKey="Kim S" first="Se Hun" last="Kim">Se Hun Kim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Choi, Eun Chang" sort="Choi, Eun Chang" uniqKey="Choi E" first="Eun Chang" last="Choi">Eun Chang Choi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Koo, Dong Hoe" sort="Koo, Dong Hoe" uniqKey="Koo D" first="Dong Hoe" last="Koo">Dong Hoe Koo</name><affiliation wicri:level="3"><nlm:affiliation>Division of Hematology/Oncology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Hematology/Oncology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Sohn, Jin Hee" sort="Sohn, Jin Hee" uniqKey="Sohn J" first="Jin Hee" last="Sohn">Jin Hee Sohn</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pathology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Bomi" sort="Kim, Bomi" uniqKey="Kim B" first="Bomi" last="Kim">Bomi Kim</name><affiliation wicri:level="3"><nlm:affiliation>Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kwon, Nak Jung" sort="Kwon, Nak Jung" uniqKey="Kwon N" first="Nak-Jung" last="Kwon">Nak-Jung Kwon</name><affiliation wicri:level="3"><nlm:affiliation>Macrogen Inc., Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Macrogen Inc., Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yun, Hwan Jung" sort="Yun, Hwan Jung" uniqKey="Yun H" first="Hwan Jung" last="Yun">Hwan Jung Yun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology-Oncology, Chungnam National University, Daejeon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Hematology-Oncology, Chungnam National University, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Min Goo" sort="Lee, Min Goo" uniqKey="Lee M" first="Min Goo" last="Lee">Min Goo Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pharmacology, Pharmacogenomic Research Center for Membrane Transporters, Brain Korea 21 PLUS Project for Medical Science, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pharmacology, Pharmacogenomic Research Center for Membrane Transporters, Brain Korea 21 PLUS Project for Medical Science, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Ji Hyun" sort="Lee, Ji Hyun" uniqKey="Lee J" first="Ji Hyun" last="Lee">Ji Hyun Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oral Biology, College of Dentistry, Yonsei University, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Oral Biology, College of Dentistry, Yonsei University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Tae Min" sort="Kim, Tae Min" uniqKey="Kim T" first="Tae-Min" last="Kim">Tae-Min Kim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Hye Ryun" sort="Kim, Hye Ryun" uniqKey="Kim H" first="Hye Ryun" last="Kim">Hye Ryun Kim</name><affiliation wicri:level="3"><nlm:affiliation>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Joo Hang" sort="Kim, Joo Hang" uniqKey="Kim J" first="Joo Hang" last="Kim">Joo Hang Kim</name><affiliation wicri:level="3"><nlm:affiliation>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Paik, Soonmyung" sort="Paik, Soonmyung" uniqKey="Paik S" first="Soonmyung" last="Paik">Soonmyung Paik</name><affiliation wicri:level="3"><nlm:affiliation>Division of Pathology NSABP, Pittsburgh, Pennsylvania. Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Pathology NSABP, Pittsburgh, Pennsylvania. Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Cho, Byoung Chul" sort="Cho, Byoung Chul" uniqKey="Cho B" first="Byoung Chul" last="Cho">Byoung Chul Cho</name><affiliation wicri:level="3"><nlm:affiliation>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul, Korea. cbc1971@yuhs.ac.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25424851</idno><idno type="pmid">25424851</idno><idno type="doi">10.1158/1078-0432.CCR-14-1756</idno><idno type="wicri:Area/PubMed/Corpus">000739</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000739</idno><idno type="wicri:Area/PubMed/Curation">000739</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000739</idno><idno type="wicri:Area/PubMed/Checkpoint">000739</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000739</idno><idno type="wicri:Area/Ncbi/Merge">003F60</idno><idno type="wicri:Area/Ncbi/Curation">003F60</idno><idno type="wicri:Area/Ncbi/Checkpoint">003F60</idno><idno type="wicri:doubleKey">1078-0432:2015:Kim H:phase:ii:clinical</idno><idno type="wicri:Area/Main/Merge">000382</idno><idno type="wicri:Area/Main/Curation">000382</idno><idno type="wicri:Area/Main/Exploration">000382</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Phase II clinical and exploratory biomarker study of dacomitinib in patients with recurrent and/or metastatic squamous cell carcinoma of head and neck.</title><author><name sortKey="Kim, Han Sang" sort="Kim, Han Sang" uniqKey="Kim H" first="Han Sang" last="Kim">Han Sang Kim</name><affiliation wicri:level="3"><nlm:affiliation>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul, Korea. Department of Pharmacology, Pharmacogenomic Research Center for Membrane Transporters, Brain Korea 21 PLUS Project for Medical Science, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul, Korea. Department of Pharmacology, Pharmacogenomic Research Center for Membrane Transporters, Brain Korea 21 PLUS Project for Medical Science, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kwon, Hyeong Ju" sort="Kwon, Hyeong Ju" uniqKey="Kwon H" first="Hyeong Ju" last="Kwon">Hyeong Ju Kwon</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pathology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jung, Inkyung" sort="Jung, Inkyung" uniqKey="Jung I" first="Inkyung" last="Jung">Inkyung Jung</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biostatistics, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biostatistics, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yun, Mi Ran" sort="Yun, Mi Ran" uniqKey="Yun M" first="Mi Ran" last="Yun">Mi Ran Yun</name><affiliation wicri:level="1"><nlm:affiliation>JE UK Institute for Cancer Research, Gumi City, Kyungbuk, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>JE UK Institute for Cancer Research, Gumi City, Kyungbuk</wicri:regionArea><wicri:noRegion>Kyungbuk</wicri:noRegion></affiliation></author><author><name sortKey="Ahn, Myung Ju" sort="Ahn, Myung Ju" uniqKey="Ahn M" first="Myung-Ju" last="Ahn">Myung-Ju Ahn</name><affiliation wicri:level="3"><nlm:affiliation>Samsung Medical Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Samsung Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kang, Byung Woog" sort="Kang, Byung Woog" uniqKey="Kang B" first="Byung Woog" last="Kang">Byung Woog Kang</name><affiliation wicri:level="1"><nlm:affiliation>Kyungpook National University Hospital, Daegu, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Kyungpook National University Hospital, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Jong Mu" sort="Sun, Jong Mu" uniqKey="Sun J" first="Jong-Mu" last="Sun">Jong-Mu Sun</name><affiliation wicri:level="3"><nlm:affiliation>Samsung Medical Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Samsung Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Sung Bae" sort="Kim, Sung Bae" uniqKey="Kim S" first="Sung Bae" last="Kim">Sung Bae Kim</name><affiliation wicri:level="3"><nlm:affiliation>Asan Medical Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Asan Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yoon, Dok Hyun" sort="Yoon, Dok Hyun" uniqKey="Yoon D" first="Dok-Hyun" last="Yoon">Dok-Hyun Yoon</name><affiliation wicri:level="3"><nlm:affiliation>Asan Medical Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Asan Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Keon Uk" sort="Park, Keon Uk" uniqKey="Park K" first="Keon Uk" last="Park">Keon Uk Park</name><affiliation wicri:level="1"><nlm:affiliation>Keimyung University, Daegu, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Keimyung University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Se Hoon" sort="Lee, Se Hoon" uniqKey="Lee S" first="Se-Hoon" last="Lee">Se-Hoon Lee</name><affiliation wicri:level="3"><nlm:affiliation>Seoul National University Hospital, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul National University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Koh, Yoon Woo" sort="Koh, Yoon Woo" uniqKey="Koh Y" first="Yoon Woo" last="Koh">Yoon Woo Koh</name><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Se Hun" sort="Kim, Se Hun" uniqKey="Kim S" first="Se Hun" last="Kim">Se Hun Kim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Choi, Eun Chang" sort="Choi, Eun Chang" uniqKey="Choi E" first="Eun Chang" last="Choi">Eun Chang Choi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Koo, Dong Hoe" sort="Koo, Dong Hoe" uniqKey="Koo D" first="Dong Hoe" last="Koo">Dong Hoe Koo</name><affiliation wicri:level="3"><nlm:affiliation>Division of Hematology/Oncology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Hematology/Oncology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Sohn, Jin Hee" sort="Sohn, Jin Hee" uniqKey="Sohn J" first="Jin Hee" last="Sohn">Jin Hee Sohn</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pathology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Bomi" sort="Kim, Bomi" uniqKey="Kim B" first="Bomi" last="Kim">Bomi Kim</name><affiliation wicri:level="3"><nlm:affiliation>Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kwon, Nak Jung" sort="Kwon, Nak Jung" uniqKey="Kwon N" first="Nak-Jung" last="Kwon">Nak-Jung Kwon</name><affiliation wicri:level="3"><nlm:affiliation>Macrogen Inc., Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Macrogen Inc., Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yun, Hwan Jung" sort="Yun, Hwan Jung" uniqKey="Yun H" first="Hwan Jung" last="Yun">Hwan Jung Yun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology-Oncology, Chungnam National University, Daejeon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Hematology-Oncology, Chungnam National University, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Min Goo" sort="Lee, Min Goo" uniqKey="Lee M" first="Min Goo" last="Lee">Min Goo Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pharmacology, Pharmacogenomic Research Center for Membrane Transporters, Brain Korea 21 PLUS Project for Medical Science, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pharmacology, Pharmacogenomic Research Center for Membrane Transporters, Brain Korea 21 PLUS Project for Medical Science, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Ji Hyun" sort="Lee, Ji Hyun" uniqKey="Lee J" first="Ji Hyun" last="Lee">Ji Hyun Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oral Biology, College of Dentistry, Yonsei University, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Oral Biology, College of Dentistry, Yonsei University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Tae Min" sort="Kim, Tae Min" uniqKey="Kim T" first="Tae-Min" last="Kim">Tae-Min Kim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Hye Ryun" sort="Kim, Hye Ryun" uniqKey="Kim H" first="Hye Ryun" last="Kim">Hye Ryun Kim</name><affiliation wicri:level="3"><nlm:affiliation>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Joo Hang" sort="Kim, Joo Hang" uniqKey="Kim J" first="Joo Hang" last="Kim">Joo Hang Kim</name><affiliation wicri:level="3"><nlm:affiliation>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Paik, Soonmyung" sort="Paik, Soonmyung" uniqKey="Paik S" first="Soonmyung" last="Paik">Soonmyung Paik</name><affiliation wicri:level="3"><nlm:affiliation>Division of Pathology NSABP, Pittsburgh, Pennsylvania. Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Pathology NSABP, Pittsburgh, Pennsylvania. Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Cho, Byoung Chul" sort="Cho, Byoung Chul" uniqKey="Cho B" first="Byoung Chul" last="Cho">Byoung Chul Cho</name><affiliation wicri:level="3"><nlm:affiliation>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul, Korea. cbc1971@yuhs.ac.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Clinical cancer research : an official journal of the American Association for Cancer Research</title><idno type="ISSN">1078-0432</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antineoplastic Agents (administration & dosage)</term><term>Antineoplastic Agents (adverse effects)</term><term>Antineoplastic Agents (therapeutic use)</term><term>Biomarkers</term><term>Carcinoma, Squamous Cell (drug therapy)</term><term>Carcinoma, Squamous Cell (genetics)</term><term>Carcinoma, Squamous Cell (mortality)</term><term>Carcinoma, Squamous Cell (pathology)</term><term>Cluster Analysis</term><term>Female</term><term>Gene Dosage</term><term>Gene Expression Profiling</term><term>Head and Neck Neoplasms (drug therapy)</term><term>Head and Neck Neoplasms (genetics)</term><term>Head and Neck Neoplasms (mortality)</term><term>Head and Neck Neoplasms (pathology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Neoplasm Metastasis</term><term>Neoplasm Recurrence, Local</term><term>Prognosis</term><term>Protein Kinase Inhibitors (administration & dosage)</term><term>Protein Kinase Inhibitors (adverse effects)</term><term>Protein Kinase Inhibitors (therapeutic use)</term><term>Quinazolinones (administration & dosage)</term><term>Quinazolinones (adverse effects)</term><term>Quinazolinones (therapeutic use)</term><term>Retreatment</term><term>Risk Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de profil d'expression de gènes</term><term>Analyse de regroupements</term><term>Antinéoplasiques (administration et posologie)</term><term>Antinéoplasiques (effets indésirables)</term><term>Antinéoplasiques (usage thérapeutique)</term><term>Carcinome épidermoïde (anatomopathologie)</term><term>Carcinome épidermoïde (génétique)</term><term>Carcinome épidermoïde (mortalité)</term><term>Carcinome épidermoïde (traitement médicamenteux)</term><term>Dosage génique</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Inhibiteurs de protéines kinases (administration et posologie)</term><term>Inhibiteurs de protéines kinases (effets indésirables)</term><term>Inhibiteurs de protéines kinases (usage thérapeutique)</term><term>Marqueurs biologiques</term><term>Mutation</term><term>Mâle</term><term>Métastase tumorale</term><term>Pronostic</term><term>Quinazolinones (administration et posologie)</term><term>Quinazolinones (effets indésirables)</term><term>Quinazolinones (usage thérapeutique)</term><term>Reprise du traitement</term><term>Récidive tumorale locale</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs de la tête et du cou (anatomopathologie)</term><term>Tumeurs de la tête et du cou (génétique)</term><term>Tumeurs de la tête et du cou (mortalité)</term><term>Tumeurs de la tête et du cou (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antineoplastic Agents</term><term>Protein Kinase Inhibitors</term><term>Quinazolinones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antineoplastic Agents</term><term>Protein Kinase Inhibitors</term><term>Quinazolinones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents</term><term>Protein Kinase Inhibitors</term><term>Quinazolinones</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antinéoplasiques</term><term>Inhibiteurs de protéines kinases</term><term>Quinazolinones</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs de la tête et du cou</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antinéoplasiques</term><term>Inhibiteurs de protéines kinases</term><term>Quinazolinones</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs de la tête et du cou</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs de la tête et du cou</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs de la tête et du cou</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques</term><term>Inhibiteurs de protéines kinases</term><term>Quinazolinones</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Biomarkers</term><term>Cluster Analysis</term><term>Female</term><term>Gene Dosage</term><term>Gene Expression Profiling</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Neoplasm Metastasis</term><term>Neoplasm Recurrence, Local</term><term>Prognosis</term><term>Retreatment</term><term>Risk Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de profil d'expression de gènes</term><term>Analyse de regroupements</term><term>Dosage génique</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Marqueurs biologiques</term><term>Mutation</term><term>Mâle</term><term>Métastase tumorale</term><term>Pronostic</term><term>Reprise du traitement</term><term>Récidive tumorale locale</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The goals of this study were to investigate the clinical activity, safety, and biomarkers of dacomitinib, an irreversible tyrosine kinase inhibitor of EGFR, HER2, and HER4, in recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M-SCCHN).</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Han Sang" sort="Kim, Han Sang" uniqKey="Kim H" first="Han Sang" last="Kim">Han Sang Kim</name></region><name sortKey="Ahn, Myung Ju" sort="Ahn, Myung Ju" uniqKey="Ahn M" first="Myung-Ju" last="Ahn">Myung-Ju Ahn</name><name sortKey="Cho, Byoung Chul" sort="Cho, Byoung Chul" uniqKey="Cho B" first="Byoung Chul" last="Cho">Byoung Chul Cho</name><name sortKey="Choi, Eun Chang" sort="Choi, Eun Chang" uniqKey="Choi E" first="Eun Chang" last="Choi">Eun Chang Choi</name><name sortKey="Jung, Inkyung" sort="Jung, Inkyung" uniqKey="Jung I" first="Inkyung" last="Jung">Inkyung Jung</name><name sortKey="Kang, Byung Woog" sort="Kang, Byung Woog" uniqKey="Kang B" first="Byung Woog" last="Kang">Byung Woog Kang</name><name sortKey="Kim, Bomi" sort="Kim, Bomi" uniqKey="Kim B" first="Bomi" last="Kim">Bomi Kim</name><name sortKey="Kim, Hye Ryun" sort="Kim, Hye Ryun" uniqKey="Kim H" first="Hye Ryun" last="Kim">Hye Ryun Kim</name><name sortKey="Kim, Joo Hang" sort="Kim, Joo Hang" uniqKey="Kim J" first="Joo Hang" last="Kim">Joo Hang Kim</name><name sortKey="Kim, Se Hun" sort="Kim, Se Hun" uniqKey="Kim S" first="Se Hun" last="Kim">Se Hun Kim</name><name sortKey="Kim, Sung Bae" sort="Kim, Sung Bae" uniqKey="Kim S" first="Sung Bae" last="Kim">Sung Bae Kim</name><name sortKey="Kim, Tae Min" sort="Kim, Tae Min" uniqKey="Kim T" first="Tae-Min" last="Kim">Tae-Min Kim</name><name sortKey="Koh, Yoon Woo" sort="Koh, Yoon Woo" uniqKey="Koh Y" first="Yoon Woo" last="Koh">Yoon Woo Koh</name><name sortKey="Koo, Dong Hoe" sort="Koo, Dong Hoe" uniqKey="Koo D" first="Dong Hoe" last="Koo">Dong Hoe Koo</name><name sortKey="Kwon, Hyeong Ju" sort="Kwon, Hyeong Ju" uniqKey="Kwon H" first="Hyeong Ju" last="Kwon">Hyeong Ju Kwon</name><name sortKey="Kwon, Nak Jung" sort="Kwon, Nak Jung" uniqKey="Kwon N" first="Nak-Jung" last="Kwon">Nak-Jung Kwon</name><name sortKey="Lee, Ji Hyun" sort="Lee, Ji Hyun" uniqKey="Lee J" first="Ji Hyun" last="Lee">Ji Hyun Lee</name><name sortKey="Lee, Min Goo" sort="Lee, Min Goo" uniqKey="Lee M" first="Min Goo" last="Lee">Min Goo Lee</name><name sortKey="Lee, Se Hoon" sort="Lee, Se Hoon" uniqKey="Lee S" first="Se-Hoon" last="Lee">Se-Hoon Lee</name><name sortKey="Paik, Soonmyung" sort="Paik, Soonmyung" uniqKey="Paik S" first="Soonmyung" last="Paik">Soonmyung Paik</name><name sortKey="Park, Keon Uk" sort="Park, Keon Uk" uniqKey="Park K" first="Keon Uk" last="Park">Keon Uk Park</name><name sortKey="Sohn, Jin Hee" sort="Sohn, Jin Hee" uniqKey="Sohn J" first="Jin Hee" last="Sohn">Jin Hee Sohn</name><name sortKey="Sun, Jong Mu" sort="Sun, Jong Mu" uniqKey="Sun J" first="Jong-Mu" last="Sun">Jong-Mu Sun</name><name sortKey="Yoon, Dok Hyun" sort="Yoon, Dok Hyun" uniqKey="Yoon D" first="Dok-Hyun" last="Yoon">Dok-Hyun Yoon</name><name sortKey="Yun, Hwan Jung" sort="Yun, Hwan Jung" uniqKey="Yun H" first="Hwan Jung" last="Yun">Hwan Jung Yun</name><name sortKey="Yun, Mi Ran" sort="Yun, Mi Ran" uniqKey="Yun M" first="Mi Ran" last="Yun">Mi Ran Yun</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000382 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000382 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25424851
|texte= Phase II clinical and exploratory biomarker study of dacomitinib in patients with recurrent and/or metastatic squamous cell carcinoma of head and neck.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25424851" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |